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- Title
Kinetics and Mechanism of Synthesis of Novocaine in the Presence of Palladium-Containing Polymers.
- Authors
Abdullaev, M.; Abdullaeva, Z.; Klyuev, M.; Gebekova, Z.
- Abstract
The kinetics and mechanism of hydrogenation of p-nitrobenzoic acid ethyl ester and transesterification of the resulting Anestezin (benzocaine) by diethylaminoethanol on palladium-containing polymers were studied. The kinetic data obtained here suggest a mechanism for transesterification in the presence of acid and alkali. Free functional groups of the weakly basic and strongly basic anion resins are shown to be involved in transesterification. An improved method for preparing novocaine in mild conditions ( t = 45°C, hydrogen pressure 1 atm.) is proposed; this is more efficient than the industrial process.
- Subjects
PROCAINE; PALLADIUM; POLYMER analysis; CHEMICAL synthesis; CHEMICAL kinetics; HYDROGENATION; NITROBENZOIC acid
- Publication
Pharmaceutical Chemistry Journal, 2014, Vol 48, Issue 5, p343
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-014-1107-6