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- Title
Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion.
- Authors
Yong-xi Song; Jing-xu Sun; Zhao, Jun-hua; Yu-chong Yang; Jin-xin Shi; Zhong-hua Wu; Xiao-wan Chen; Peng Gao; Zhi-feng Miao; Zhen-ning Wan
- Abstract
Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into "networks" based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p. In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competing endogenous RNAs to affect the function of Claudin-4. Our results suggest that non-coding RNAs play important roles in the regulatory network of Claudin-4. As such, non-coding RNAs should be considered as potential biomarkers and therapeutic targets against gastric cancer.
- Subjects
NON-coding RNA; CLAUDINS; MICRORNA; STOMACH cancer; CANCER invasiveness; RNA
- Publication
Nature Communications, 2017, Vol 8, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-017-00304-1