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- Title
A Single Session of Low-Intensity Exercise Is Sufficient to Enhance Insulin Sensitivity Into the Next Day in Obese Adults.
- Authors
NEWSOM, SEAN A.; EVERETT, ALLISON C.; HINKO, ALEXANDER; HOROWITZ, JEFFREY F.
- Abstract
OBJECTIVE--The purpose of this study was to determine the effect of a relatively modest session of exercise on insulin sensitivity and fatty acid uptake the next day in obese adults. RESEARCH DESIGN AND METHODS--Eleven sedentary obese adults (male/female: 3/8; BMI 37 6 1 kg/m²; peak oxygen uptake [VO2peak] 20 ± 1 mL/kg/min) completed three experimental trials. On two of these occasions, subjects exercised to expend 350 kcal in the afternoon. These two exercise trials were identical except for the exercise intensity (50% VO2peak [EX50] and 65% VO2peak [EX65]) and the duration of exercise necessary to expend 350 kcal (EX50 = ~70 min; EX65 = ~55 min). Subjects also completed a control trial (CON), without exercise. The next morning, we measured insulin sensitivity (hyperinsulinemic-euglycemic clamp) and whole-body fatty acid uptake (palmitate rate of disappearance from plasma [Rd] RESULTS--Exercise increased insulin sensitivity the next day, but whereas the 35% improvement after EX50 compared with CON was statistically significant (P = 0.01), the 20% improvement after EX65 was not (P = 0.17). Despite nearly identical values between CON and EX65 (P = 0.88), systemic fatty acid uptake was lower after EX50 compared with EX65 (P = 0.02), but not quite significant compared with CON (P = 0.07). Importantly, the change in fatty acid uptake after exercise compared with CON was negatively correlated with the change in insulin sensitivity for all trials (r = 20.60, P = 0.003). CONCLUSIONS--A relatively modest single session of exercise in obese adults improved insulin sensitivity the next day, and a reduction in systemic fatty acid uptake in the several hours after exercise may be important for this effect.
- Subjects
EXERCISE therapy; INSULIN resistance; FATTY acids; OVERWEIGHT persons; AEROBIC capacity
- Publication
Diabetes Care, 2013, Vol 36, Issue 9, p2516
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc12-2606