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- Title
EFFECT OF NRF2/HO-1 MODULATOR IN MERCURY INDUCED EXPERIMENTAL MODEL OF AMYOTROPHIC LATERAL SCLEROSIS IN RATS.
- Authors
Elizabeth, Minj; Sidharth, Mehan
- Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease (MND) that affect the upper and lower motor neuron (corticospinal tract) in motor cortex, basal ganglia, brain stem and spinal cord. Sign and symptoms experienced by patient in between 50 to 60 years of age included impaired motor movement, difficulty in speaking and swallowing, grip loss, respiratory failure, muscle atrophy, spasticity and sometimes associated with memory and cognitive impairments. After diagnosis median survival is 2 to 5 years and 5 to 10 % beyond 10 years of age. Currently, there are no specific diagnostic biomarkers identified for ALS. The multifunctional regulator nuclear factor erythroid 2-realed factor (Nrf2/HO-1) is considered not only as a cytoprotective factor regulating the expression of gene coding for anti-oxidant, anti-inflammatory and detoxifying protein, but also a powerful modulator of species longevity. However, neurological dysfunctions are the main pathological hallmark for the progression of ALS in centrally as well in peripherally nervous system. Therefore, we hypothesized that Nrf2/HO-1 modulation will show preventive effect in mercury induced experimental model of amyotropic lateral sclerosis in rats.
- Subjects
AMYOTROPHIC lateral sclerosis; NERVOUS system; SPINAL cord; MOTOR neurons; PYRAMIDAL tract; BRAIN stem
- Publication
International Journal of Pharmacy & Life Sciences, 2019, Vol 10, Issue 6, p51
- ISSN
0976-7126
- Publication type
Article