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- Title
Atherosclerotic background of benign prostatic hyperplasia in sickle cell diseases.
- Authors
Helvaci, Mehmet Rami; Ayyildiz, Orhan; Muftuoglu, Orhan Ekrem; Yaprak, Mustafa; Abyad, Abdulrazak; Pocock, Lesley
- Abstract
Background: Sickle cell diseases (SCDs) are accelerated atherosclerotic processes. We tried to understand whether or not there is an atherosclerotic background of benign prostatic hyperplasia in the SCDs patients. Methods: All patients with the SCDs were included into the study. Results: The study included 428 patients (220 males). The mean ages were similar in males and females (30.6 versus 30.1 years, respectively, P>0.05). Smoking (24.0% versus 6.2%) and alcohol (5.0% versus 0.4%) were significantly higher in males (P<0.001 for both). Transfused units of red blood cells in their lives (47.6 versus 28.4, P=0.000), chronic obstructive pulmonary disease (25.4% versus 7.2%, P<0.001), ileus (7.2% versus 1.4%, P<0.001), cirrhosis (7.7% versus 1.9%, P<0.001), leg ulcers (20.0% versus 7.2%, P<0.001), digital clubbing (14.0% versus 6.2%, P<0.001), coronary artery disease (18.1% versus 12.9%, P<0.05), chronic renal disease (10.4% versus 6.2%, P<0.05), and stroke (12.2% versus 7.6%, P<0.05) were all higher in males, too. There were 11 males (5.0%) with lower urinary tract symptoms (LUTS) including urgency, weak stream, incomplete emptying, and nocturia with a mean age of 41.4 years. All patients could be treated with once daily 4 milligrams of doxazosin, orally. Conclusion: SCDs are chronic inflammatory processes on vascular endothelium particularly at the capillary level, and terminate with accelerated atherosclerosis induced end-organ failures in early years of life. Although the relatively younger mean age of the patients, LUTS are probably due to the disseminated endothelial damage, inflammation, edema, and fibrosis both in the arterial and venous systems of the prostate in the SCDs.
- Subjects
SICKLE cell anemia diagnosis; SICKLE cell anemia treatment; BENIGN prostatic hyperplasia
- Publication
Middle East Journal of Internal Medicine, 2017, Vol 10, Issue 1, p3
- ISSN
1837-9052
- Publication type
Article
- DOI
10.5742/MEIM.2017.92925