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- Title
Analgesic, anti-inflammatory and hypoglycaemic effects of Securidaca longepedunculata (Fresen.) [Polygalaceae] root-bark aqueous extract.
- Authors
Ojewole, J. A. O.
- Abstract
The present study was undertaken to investigate the analgesic, anti-inflammatory and hypoglycaemic properties of Securidaca longepedunculata (Fresen.) root-bark aqueous extract (SLE) in mice and rats. The analgesic effect of SLE was evaluated by ‘hot-plate’ and ‘acetic acid’ analgesic test methods in mice; while its anti-inflammatory and hypoglycaemic effects were examined in rats, using fresh egg albumin-induced pedal oedema, and streptozotocin (STZ)-induced diabetes mellitus models. Morphine (MPN, 10 mg/kg), diclofenac (DIC, 100 mg/kg) and chlorpropamide (250 mg/kg) were used as reference drugs for comparison. SLE (50–800 mg/kg i. p.) produced dose-dependent, significant (p < 0.05–0.001) analgesic effects against thermally- and chemically-induced nociceptive pain in mice. The plant’s extract (SLE, 50–800 mg/kg p. o.) also dose-dependently and significantly inhibited (p < 0.05–0.001) fresh egg albumin-induced acute inflammation, and caused significant hypoglycaemia (p < 0.05–0.001) in normal (normoglycaemic) and STZ-treated diabetic (hyperglycaemic) rats. The results of this experimental animal study indicate that S. longepedunculata root-bark aqueous extract (SLE) possesses analgesic, anti-inflammatory and hypoglycaemic properties. These findings lend pharmacological credence to the anecdotal, folkloric and ethnomedical uses of S. longepedunculata root-bark in the treatment, management and/or control of painful, arthritic, inflammatory conditions, as well as in the management and/or control of type 2 diabetes mellitus in some rural communities of South Africa.
- Subjects
ANALGESICS; ANTI-inflammatory agents; HYPOGLYCEMIC agents; POLYGALACEAE; PLANT extracts
- Publication
Inflammopharmacology, 2008, Vol 16, Issue 4, p174
- ISSN
0925-4692
- Publication type
Article
- DOI
10.1007/s10787-007-0016-7