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- Title
Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy.
- Authors
Oubaha, Malika; Miloudi, Khalil; Dejda, Agnieszka; Guber, Vera; Mawambo, Gaëlle; Germain, Marie-Anne; Bourdel, Guillaume; Popovic, Natalija; Rezende, Flavio A.; Kaufman, Randal J.; Mallette, Frédérick A.; Sapieha, Przemyslaw
- Abstract
The article discusses a study on the contribution of a senescence-associated secretory phenotype (SASP) to pathological angiogenesis in retinopathy. The study used transcriptomic analysis and inducible loss-of-function genetics to examine the role of ischemic retinal cells in the inducement of senescence. It detected SASP-associated cytokines in patients with proliferative diabetic retinopathy, including plasminogen activator inhibitor 1, interleukin-6 and vascular endothelial growth factor.
- Subjects
DIABETIC retinopathy; CELLULAR aging; CYTOKINES; PLASMINOGEN activator inhibitors; INTERLEUKIN-6; VASCULAR endothelial growth factors
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 362, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaf9440