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- Title
Insulin requirements in type 1 diabetic pregnancy: do twin pregnant women require twice as much insulin as singleton pregnant women?
- Authors
Callesen NF; Ringholm L; Stage E; Damm P; Mathiesen ER; Callesen, Nicoline F; Ringholm, Lene; Stage, Edna; Damm, Peter; Mathiesen, Elisabeth R
- Abstract
<bold>Objective: </bold>To evaluate the insulin requirements in women with type 1 diabetes during twin pregnancy compared with singleton pregnancy.<bold>Research Design and Methods: </bold>At 8, 14, 21, 27, and 33 gestational weeks, insulin requirements and HbA(1c) were compared between 15 twin pregnant women from 2000 to 2011 and 108 singleton pregnant women from 2004 to 2006.<bold>Results: </bold>In twin pregnancies, the weekly increase in daily insulin dose between 14 and 27 weeks was higher than in singleton pregnancies (median 3.0 international units [IU] [range 0.9-4.9] versus 1.5 IU [-1.5 to 5.9]; P = 0.008) and remained stable from 27 to 33 weeks. The increment in total insulin requirement from before pregnancy until 33 weeks tended to be higher in twin pregnancies (103% [36-257%] versus 71% [-20 to 276%]; P = 0.07). Throughout pregnancy, HbA(1c) was similar in twin and singleton pregnancies.<bold>Conclusions: </bold>In twin pregnancies, the weekly increase in insulin dose between 14 and 27 weeks was doubled compared with singleton pregnancies.
- Publication
Diabetes Care, 2012, Vol 35, Issue 6, p1246
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc11-2467