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- Title
A self-complementary macrocycle by a dual interaction system.
- Authors
Sawanaka, Yuta; Yamashina, Masahiro; Ohtsu, Hiroyoshi; Toyota, Shinji
- Abstract
Self-complementary assembly is one of the most promising phenomena for the formation of discrete assemblies, e.g., proteins and capsids. However, self-complementary assembly based on multiple host-guest systems has been scarcely reported due to the difficulty in controlling each assembly. Herein, we report a dual interaction system in which the key assembly direction is well regulated by both π-π stacking and hydrogen bonding to construct a self-complementary macrocycle. Continuous host-guest behavior of anthracene-based molecular tweezers during crystallization leads to successful construction of a cyclic hexamer, which is reminiscent of Kekulé's monkey model. Furthermore, the cyclic hexamer in a tight and triple-layered fashion shows hierarchical assembly into cuboctahedron and rhombohedral assemblies in the presence of trifluoroacetic acid. Our findings would be potentially one of metal-free strategies for constructing anthracene-based supramolecular assemblies with higher-order structure. In nature, HIV capsid consists of single class of protein unit by self-complementarity. Here, the authors find that a molecular tweezer forms a cyclic hexamer by its continuous host-guest behavior, and constructs a large cuboctahedron by hierarchical assembly.
- Subjects
TRIFLUOROACETIC acid; FASHION shows; HYDROGEN bonding; CAPSIDS; MONKEYS
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-33357-y