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- Title
3 L , Three- Lactobacilli on Recovering of Microbiome and Immune-Damage by Cyclophosphamide Chemotherapy—A Pilot Experiment in Rats.
- Authors
Yue, Shousong; Zhang, Zhenzhong; Bian, Fei; Zhang, Yan; Chen, Gao; Zhu, Youfeng; Li, Jun; Picimbon, Jean-François
- Abstract
We deal with various strains of Lactobacillus that can maintain the intestinal microbiome of rats treated with cyclophosphamide, an anticancer agent (chemotherapy). We use MiSeq and various types of statistical tests to prove that cyclophosphamide in rats alters the intestinal microbiome, favoring the growth of various fungi that are extremely harmful to intestinal metabolism. On the contrary, when Lactobacillus 3L is administered together with cyclophosphamide, we prove that the microbiome is preserved by having a much better intestinal metabolism.
- Subjects
PILOT projects; GUT microbiome; CYCLOPHOSPHAMIDE; ANTINEOPLASTIC agents; CANCER chemotherapy; RATS
- Publication
Microbiology Research, 2023, Vol 14, Issue 3, p831
- ISSN
2036-7481
- Publication type
Article
- DOI
10.3390/microbiolres14030059