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- Title
Phase 1 Clinical Study of Pegylated Liposomal Doxorubicin (JNS002) in Japanese Patients with Solid Tumors.
- Authors
Fujisaka, Yasuhito; Horiike, Atsushi; Shimizu, Toshio; Yamamoto, Noboru; Yamada, Yasuhide; Tamura, Tomohide
- Abstract
Background: Pegylated liposomal doxorubicin (PLD, JNS002) is a formulation of doxorubicin encapsulated polyethylene-glycol coated liposomes with prolonged circulation time and unique toxicity profile. This phase 1 study was aimed at investigating the maximum tolerated dose (MTD), recommended dose, toxicity, pharmacokinetics, and antitumor activity in Japanese patients with solid tumors.
- Publication
Japanese Journal of Clinical Oncology, 2006, Vol 36, Issue 12, p768
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hyl109