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- Title
Efficacy of the Angiogenesis Inhibitor O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470) on Osteosarcoma Growth and Lung Metastasis in Rats.
- Authors
Morishita, Toru; Mii, Yoshio; Miyauchi, Yoshizumi; Miura, Shuichi; Honoki, Kanya; Aoki, Makoto; Kido, Akira; Tamai, Susumu; Tsutsumi, Masahiro; Konishi, Yoichi
- Abstract
The efficacy of the anti-angiogenic agent, O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470), against primary tumor growth and spontaneous lung metastasis was evaluated experimentally using a transplantable osteosarcoma line in rats previously established in our laboratory. Male Fischer 344 rats bearing the tumor with a high potential for metastasis received intermittent or continuous subcutaneous administrations of AGM-1470. Both treatment regimens resulted in significant inhibitions of spontaneous lung metastasis and primary tumor growth in a dose-dependent manner, with continuous administration of AGM-1470 exerting the most pronounced inhibitory effects on both parameters
- Publication
Japanese Journal of Clinical Oncology, 1995, Vol 25, Issue 2, p25
- ISSN
0368-2811
- Publication type
Article