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- Title
Low Serum Adiponectin Levels in Children and Adolescents with Diabetic Retinopathy.
- Authors
Tasci, Eser; Ozbek, Mehmet Nuri; Onenli-Mungan, Neslihan; Temiz, Fati; Topaloglu, Ali Kemal; Yuksel, Bilgin
- Abstract
Objective: The aim of this study was to elucidate the role of adiponectin, leptin, TNF-α and IL-6 on the early detection of the microvascular complications of type I diabetes. Materials and Methods: A total of 88 children were included in the study. There were 60 type I diabetic patients and 28 healthy control children. Results: The gender, age, weight, height, BMI and puberty status characteristics were similar in the patient and control groups (p>0.05). The serum leptin, TNF-α and IL-6 levels were similar between the patient and control groups (p>0.05) and the only diff erence was in the serum adiponectin level which was higher in the patient group (p:0.042). We also found no association between the adiponectin, leptin, TNF-α and IL-6 levels and diabetes duration (p>0.05). Leptin was high in the pubertal period (p:0.016), while adiponectin TNF-α and IL-6 levels were similar in the prepubertal and pubertal periods (p>0.05). The serum leptin level was high in microalbuminuria patients (p<0.041). The serum adiponectin, TNF-α, and IL-6 levels were not diff erent in patients with and without microalbuminuria (p>0.05). The serum adiponectin level was lower in diabetic retinopathy patients (p:0.003), while the serum leptin level was higher (p:0.003). The TNF-α and IL-6 levels were similar in patients with and without retinopathy (p>0.05). Conclusion: We found increased serum adinopectin levels in children and adolescents with type I diabetes mellitus and low levels in diabetic retinopathy patients. Patients with low serum adiponectin levels and high leptin levels should be more closely monitored for chronic complication development and better metabolic control should be aimed for.
- Subjects
DIABETIC retinopathy; SERUM; LEPTIN; MICROCIRCULATION disorders; DIABETES complications in children; DIABETES in adolescence; CONTROL groups; DISEASE duration; METABOLIC regulation
- Publication
Eurasian Journal of Medicine, 2011, Vol 43, Issue 1, p18
- ISSN
1308-8734
- Publication type
Article
- DOI
10.5152/eajm.2011.04