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- Title
Neurophysiological Indices of Atypical Auditory Processing and Multisensory Integration are Associated with Symptom Severity in Autism.
- Authors
Brandwein, Alice; Foxe, John; Butler, John; Frey, Hans-Peter; Bates, Juliana; Shulman, Lisa; Molholm, Sophie
- Abstract
Atypical processing and integration of sensory inputs are hypothesized to play a role in unusual sensory reactions and social-cognitive deficits in autism spectrum disorder (ASD). Reports on the relationship between objective metrics of sensory processing and clinical symptoms, however, are surprisingly sparse. Here we examined the relationship between neurophysiological assays of sensory processing and (1) autism severity and (2) sensory sensitivities, in individuals with ASD aged 6-17. Multiple linear regression indicated significant associations between neural markers of auditory processing and multisensory integration, and autism severity. No such relationships were apparent for clinical measures of visual/auditory sensitivities. These data support that aberrant early sensory processing contributes to autism symptoms, and reveal the potential of electrophysiology to objectively subtype autism.
- Subjects
AUDITORY perception; AUTISM; ELECTROPHYSIOLOGY; EXPERIMENTAL design; NEUROPHYSIOLOGY; SENSES; MULTIPLE regression analysis; SEVERITY of illness index; SYMPTOMS; CHILDREN
- Publication
Journal of Autism & Developmental Disorders, 2015, Vol 45, Issue 1, p230
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-014-2212-9