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- Title
Antioxidant activities of dithiol alpha-lipoic acid.
- Authors
Islam, M. T.
- Abstract
Alpha-lipoic acid, a dithiol compound derived from octanoic acid, which acts as a coenzyme for several redox reactions in almost all the tissue of the body. It retains its protective functions in both oxidized and reduced forms. Alpha-lipoic acid reduces oxidative stress by redox generation of other antioxidants such as vitamin C, E and increasing the intracellular glutathione. Exogenous alpha-lipoic acid has been shown to increase ATP production due to its role in the oxidation of pyruvate and alpha-ketoglutarate in the mitochondria. Alpha-lipoic acid administration has been shown to be effective in preventing pathology in various experimental models in which reactive oxygen species have been implicated.
- Subjects
LIPOIC acid; COENZYMES; OXIDATION-reduction reaction; OXIDATIVE stress; ANTIOXIDANTS; GLUTATHIONE; ADENOSINE triphosphate; PYRUVATES; MITOCHONDRIA
- Publication
Bangladesh Journal of Medical Science, 2009, Vol 8, Issue 3, p6
- ISSN
2223-4721
- Publication type
Article