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- Title
Experimental Protocol and Phantom Design and Development for Performance Characterization of Conventional Devices for Peripheral Vascular Interventions.
- Authors
Alawneh, Yara; Zhou, James J.; Sewani, Alykhan; Tahmasebi, Mohammadmahdi; Roy, Trisha L.; Kayssi, Ahmed; Dueck, Andrew D.; Wright, Graham A.; Tavallaei, M. Ali
- Abstract
Conventional catheter-based interventions for treating peripheral artery disease suffer high failure and complication rates. The mechanical interactions with the anatomy constrain catheter controllability, while their length and flexibility limit their pushability. Also, the 2D X-ray fluoroscopy guiding these procedures fails to provide sufficient feedback about the device location relative to the anatomy. Our study aims to quantify the performance of conventional non-steerable (NS) and steerable (S) catheters in phantom and ex vivo experiments. In a 10 mm diameter, 30 cm long artery phantom model, with four operators, we evaluated the success rate and crossing time in accessing 1.25 mm target channels, the accessible workspace, and the force delivered through each catheter. For clinical relevance, we evaluated the success rate and crossing time in crossing ex vivo chronic total occlusions. For the S and NS catheters, respectively, users successfully accessed 69 and 31% of the targets, 68 and 45% of the cross-sectional area, and could deliver 14.2 and 10.2 g of mean force. Using a NS catheter, users crossed 0.0 and 9.5% of the fixed and fresh lesions, respectively. Overall, we quantified the limitations of conventional catheters (navigation, reachable workspace, and pushability) for peripheral interventions; this can serve as a basis for comparison with other devices.
- Subjects
CHRONIC total occlusion; COLLATERAL circulation; PERIPHERAL vascular diseases
- Publication
Annals of Biomedical Engineering, 2023, Vol 51, Issue 7, p1547
- ISSN
0090-6964
- Publication type
Article
- DOI
10.1007/s10439-023-03160-x