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- Title
JAK2 Is Constitutively Associated with c-Kit and Is Phosphorylated in Response to Stem Cell Factor.
- Authors
Linnekin, Diana; Weiler, Sarah R.; Mou, Sherry; DeBerry, Candy S.; Keller, Jonathan R.; Ruscetti, Francis W.; Ferris, Douglas K.; Longo, Dan L.
- Abstract
Stem cell factor (SCF) interacts with the receptor tyrosine kinase c-Kit and has potent effects on hematopoiesis. We have examined the role of JAK2 in the SCF signal transduction pathway. JAK2 and c-Kit were constitutively associated, and treatment with SCF resulted in rapid and transient tyrosine phosphorylation of JAK2. Incubation of cells with JAK2 antisense oligonucleotides resulted in significant decreases in SCF-induced proliferation. These data suggest that JAK2 plays a role in SCF-induced proliferation. Copyright © 1996 S. Karger AG, Basel
- Publication
Acta Haematologica, 1996, Vol 95, Issue 3/4, p224
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000203882