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- Title
The efficacy of dietary curcumin on growth performance, lipid peroxidation and hepatic transcription factors in rainbow trout Oncorhynchus Mykiss (Walbaum) reared under different stocking densities.
- Authors
Akdemir, Fatih; Orhan, Cemal; Tuzcu, Mehmet; Sahin, Nurhan; Juturu, Vijaya; Sahin, Kazim
- Abstract
Curcumin, derived from Curcuma longa, exerts antioxidant, antibacterial, anticancer and immunomodulatory properties. This study was conducted to determine the effect of dietary water-soluble curcumin (0, 200 or 400 mg kg−1) on growth performance and antioxidant status in rainbow trout ( Oncorhynchus mykiss, Walbaum) rearing under normal (20 kg m−3) or high (100 kg m−3) stocking density conditions. A significant increase in body weight ( FBW), feed intake ( FI) and weight gain ( BWG) was observed in fish fed with curcumin-supplemented diet at 200 mg kg−1 of diet levels of high stocking density conditions ( P < 0.0001), whereas feed conversion ratio ( FCR) was not significant. Also, serum and liver malondialdehyde ( MDA) levels were decreased by dietary curcumin in crowded fish ( P < 0.01, for both). With curcumin supplementation, expressions of heat shock protein 70 ( HSP70; P < 0.0001) and hepatic nuclear factor kappa-B ( NF-κB; P < 0.01) decreased, whereas expressions of hepatic nuclear factor erythroid 2 ( NF-E2)-related factor 2 (Nrf2) and heme oxygenase 1 ( HO-1) ( P < 0.001, for both) increased in fish exposed to high stocking density. In conclusion, curcumin supplementation alleviates adverse effects of high stocking density on performance through modulating expressions of stress-related nuclear transcription factors in rainbow trout.
- Subjects
CURCUMIN; RAINBOW trout; LIPID peroxidation (Biology); TRANSCRIPTION factors; HEAT shock proteins
- Publication
Aquaculture Research, 2017, Vol 48, Issue 8, p4012
- ISSN
1355-557X
- Publication type
Article
- DOI
10.1111/are.13223