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- Title
Evidence for Widespread GC-biased Gene Conversion in Eukaryotes.
- Authors
Pessia, Eugénie; Popa, Alexandra; Mousset, Sylvain; Rezvoy, Clément; Duret, Laurent; Marais, Gabriel A. B.
- Abstract
GC-biased gene conversion (gBGC) is a process that tends to increase the GC content of recombining DNA over evolutionary time and is thought to explain the evolution of GC content in mammals and yeasts. Evidence for gBGC outside these two groups is growing but is still limited. Here, we analyzed 36 completely sequenced genomes representing four of the five major groups in eukaryotes (Unikonts, Excavates, Chromalveolates and Plantae). gBGC was investigated by directly comparing GC content and recombination rates in species where recombination data are available, that is, half of them. To study all species of our dataset, we used chromosome size as a proxy for recombination rate and compared it with GC content. Among the 17 species showing a significant relationship between GC content and chromosome size, 15 are consistent with the predictions of the gBGC model. Importantly, the species showing a pattern consistent with gBGC are found in all the four major groups of eukaryotes studied, which suggests that gBGC may be widespread in eukaryotes.
- Subjects
GENE conversion; EUKARYOTES; RECOMBINANT DNA; GENETIC recombination; YEAST fungi genetics; FUNGAL chromosomes; MAMMALS
- Publication
Genome Biology & Evolution, 2012, Vol 4, Issue 7, p675
- ISSN
1759-6653
- Publication type
Article
- DOI
10.1093/gbe/evs052