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- Title
Combined effects of fluoxetine and triclosan on Pseudorasbora parva.
- Authors
MU Lei; YAN Liang; XIE Ling-dan; CHEN Hong-xing; GUO Zhong-bao; LUO Yong-ju
- Abstract
We examined the effects of binary mixture of two different pharmaceutical and personal care products (PPCPs) on aquatic organisms. The topmouth gudgeon Pseudorasbora parva, native to northeast China, was used to study the combined effects of fluoxetine (FLX) and triclosan (TCS) on its different organs. After acute (4 h) and chronic (42 d) treatments, the combined effects of FLX/TCS on phase I and phase II detoxification enzymes, nervous system, digestive system and antioxidant system were evaluated. The results showed that the AChE activity in the brain of P. parva was transiently inhibited, whereas the activity of EROD in the liver was continuously inhibited. The activity of α-Glu in the intestine was induced after acute exposure but was inhibited after chronic exposure. Meanwhile, the level of lipid peroxidation in the liver was elevated after chronic exposure. In conclusion, the mixture of fluoxetine and triclosan produced toxic effects on multiple organs of P. parva, which could be alleviated after profonged exposure, indicating an acclimation. However, the mechanisms of this acclimation needed further study.
- Publication
Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao, 2018, Vol 29, Issue 9, p3058
- ISSN
1001-9332
- Publication type
Article
- DOI
10.13287/j.1001-9332.201809.038