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- Title
miRNA-451a Targets IFN Regulatory Factor 8 for the Progression of Systemic Lupus Erythematosus.
- Authors
Cheng, Jia; Wu, Rui; Long, Li; Su, Jiang; Liu, Jian; Wu, Xiao-Dan; Zhu, Jing; Zhou, Bin
- Abstract
Increasing evidence has shown that miRNA-451a (miR-451a) is associated with the development of systemic lupus erythematosus (SLE); however, the mechanism of this association is not fully known. The present study found an increased expression of miR-451a in the spleen and thymus of an SLE mice model. A decrease in miR-451a expression partly relieved the enlargement of the spleen and decreased the proteinuria content and immune complex deposits. The deficiency in miR-451a also decreased numbers of CD4+CD69+ and CD4+/CD8+ T cells and the levels of the serum cytokines IL-17a and IL-4. The IFN regulatory factor (IRF) 8 was highly expressed in the immune organs of wild-type mice but was suppressed in SLE-like mice. A dual-luciferase reporter assay was carried out in combination with gene silencing and overexpression to verify that IRF8 was a target of miR-451a in vitro and in vivo. The data indicate the function and a target of miR-451a in SLE, providing a new target for SLE therapy.
- Subjects
SYSTEMIC lupus erythematosus treatment; IMMUNE complexes; GENE silencing; MICRORNA; INTERLEUKIN-17; INTERLEUKIN-4
- Publication
Inflammation, 2017, Vol 40, Issue 2, p676
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-017-0514-8