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- Title
Benefit-risk Evaluation for Diagnostics: A Framework (BED-FRAME).
- Authors
Evans, Scott R.; Pennello, Gene; Pantoja-Galicia, Norberto; Hongyu Jiang; Hujer, Andrea M.; Hujer, Kristine M.; Manca, Claudia; Hill, Carol; Jacobs, Michael R.; Liang Chen; Patel, Robin; Kreiswirth, Barry N.; Bonomo, Robert A.
- Abstract
The medical community needs systematic and pragmatic approaches for evaluating the benefit-risk trade-offs of diagnostics that assist in medical decision making. Benefit-Risk Evaluation of Diagnostics: A Framework (BED-FRAME) is a strategy for pragmatic evaluation of diagnostics designed to supplement traditional approaches. BED-FRAME evaluates diagnostic yield and addresses 2 key issues: (1) that diagnostic yield depends on prevalence, and (2) that different diagnostic errors carry different clinical consequences. As such, evaluating and comparing diagnostics depends on prevalence and the relative importance of potential errors. BED-FRAME provides a tool for communicating the expected clinical impact of diagnostic application and the expected tradeoffs of diagnostic alternatives. BED-FRAME is a useful fundamental supplement to the standard analysis of diagnostic studies that will aid in clinical decision making.
- Subjects
MEDICAL decision making; DISEASE prevalence; DIAGNOSTIC imaging; DIAGNOSTIC errors; DIAGNOSIS
- Publication
Clinical Infectious Diseases, 2016, Vol 63, Issue 6, p812
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciw329