We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Targeting NAD-dependent dehydrogenases in drug discovery against infectious diseases and cancer.
- Authors
Ferraris, Davide M.; Gelardi, Edoardo L. M.; Garavaglia, Silvia; Miggiano, Riccardo; Rizzi, Menico
- Abstract
Dehydrogenases are oxidoreductase enzymes that play a variety of fundamental functions in the living organisms and have primary roles in pathogen survival and infection processes as well as in cancer development. We review here a sub-set of NAD-dependent dehydrogenases involved in human diseases and the recent advancements in drug development targeting pathogen-associated NAD-dependent dehydrogenases. We focus also on the molecular aspects of the inhibition process listing the structures of the most relevant molecules targeting this enzyme family. Our aim is to review the most impacting findings regarding the discovery of novel inhibitory compounds targeting the selected NAD-dependent dehydrogenases involved in cancer and infectious diseases.
- Subjects
DEHYDROGENASES; COMMUNICABLE diseases; GLUCOSE-6-phosphate dehydrogenase; DRUG development; OXIDOREDUCTASES; CANCER; TARGETED drug delivery
- Publication
Biochemical Society Transactions, 2020, Vol 48, Issue 2, p693
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20191261