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- Title
High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented mothers are related to less immunoglobulin E-associated disease in infancy.
- Authors
Warstedt, Kristina; Furuhjelm, Catrin; Fälth‐Magnusson, Karin; Fagerås, Malin; Duchén, Karel
- Abstract
<bold>Aim: </bold>We previously reported a protective effect of maternal omega-3 fatty acid supplements on the development of immunoglobulin E (IgE)-associated disease in infancy. This study assessed omega-3 long-chain polyunsaturated fatty acids (LCPUFA) in maternal milk in relation to omega-3 LCPUFA supplementation and the development of allergic disease in their infants.<bold>Methods: </bold>This study randomised 95 pregnant women at risk of having an allergic infant, to daily supplements of 2.6 g omega-3 LCPUFA or a placebo of 2.7 g soya bean oil from gestational week 25 until 3 months of lactation. Breast milk samples were collected as colostrum, at one and 3 months. Milk fatty acids were related to allergic outcome in the infants at 24 months.<bold>Results: </bold>Omega-3 milk fatty acids were higher in women who received omega-3 supplements than the placebo group (p < 0.01). Higher proportions of milk eicosapentaenoic acid and docosahexaenoic acid and a lower arachidonic/eicosapentaenoic acid ratio were associated with an absence of IgE-associated disease in the infants. None of the children developed IgE-associated atopic eczema above a level of 0.83 mol% eicosapentaenoic acid in colostrum. [Correction added on 7 July 2016, after online publication: In the preceding sentence, the correct word should be "above" instead of "below" and this has been amended in this current version.] CONCLUSION: High omega-3 LCPUFA milk levels in mothers who received omega-3 LCPUFA supplements were related to fewer allergies in their children.
- Subjects
OMEGA-3 fatty acids; FATTY acid content of breast milk; IMMUNOGLOBULIN E; INFANT disease prevention; ALLERGY in infants; ATOPIC dermatitis; EICOSAPENTAENOIC acid; PREVENTION
- Publication
Acta Paediatrica, 2016, Vol 105, Issue 11, p1337
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/apa.13395