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- Title
The murine telomerase catalytic subunit shares the PAb-240 mutant specific epitope of the p53 protein
- Authors
Shats, Igor; Milyavsky, Michael; Erez, Neta; Rotter, Varda
- Abstract
Many tumorigenic p53 mutants gain a common antigenic epitope that is recognized by the PAb-240 antibody. Database search identified the presence of this epitope in several other proteins, including several antibodies and the catalytic subunit of mouse telomerase, mTERT. These antibodies may represent a part of the previously demonstrated anti-idiotypic network built around p53. In the present study we demonstrate that the PAb-240 antibody was able to inhibit telomerase activity in extracts from both mouse and human tumor cells. The recognition of mTERT by PAb-240 is demonstrated by Western blotting and by using blocking peptides derived from mTERT. The existence of a shared epitope between mutant p53 and telomerase may suggest that the two proteins contribute to malignant transformation through a common pathway.
- Subjects
TELOMERASE; GENE therapy
- Publication
FEBS Letters, 2003, Vol 546, Issue 2/3, p321
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)00607-0