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- Title
The Aspergillus nidulans cyclin PclA accumulates in the nucleus and interacts with the central cell cycle regulator NimX<sup>Cdc2</sup>
- Authors
Schier, Niklas; Fischer, Reinhard
- Abstract
The filamentous fungus Aspergillus nidulans reproduces asexually through conidiospores, which are continuously generated at morphologically differentiated structures, the conidiophores. In contrast to vegetative, multinucleate cells, spore formation requires a strict coordination of mitosis and cytokinesis. It was shown recently that the key regulator of the cell cycle in A. nidulans NimXCdc2 and a G1/S cyclin, PclA, are transcriptionally upregulated during development. Here we show that PclA accumulates in the nucleus and interacts with NimXCdc2. We propose that PclA modulates the kinase activity of NimXCdc2 during spore formation.
- Subjects
ASPERGILLUS nidulans; GENETIC transcription; PROTEIN kinases; CYTOKINESIS
- Publication
FEBS Letters, 2002, Vol 523, Issue 1-3, p143
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)02964-2