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- Title
Quantification of NF1 transcripts reveals novel highly expressed splice variants
- Authors
Vandenbroucke, Ina; Vandesompele, Jo; De Paepe, Anne; Messiaen, Ludwine
- Abstract
Previously, we have shown that the NF1 gene gives rise to multiple novel splice variants. In the present study, nine NF1 variants were quantified by real-time PCR in various human tissues. Some of these variants were expressed at low to moderate low levels and possible implications of these findings are discussed. Interestingly, two variants (NF1-ΔE4b and NF1-ΔE43) were shown to be highly expressed in specific tissues. NF1-ΔE43 lacks a nuclear targeting sequence and might be functionally different from full-length NF1. These novel NF1 splice variants might expand our understanding of the role of neurofibromin.
- Subjects
NEUROFIBROMATOSIS; GENETIC regulation; GTPASE-activating protein
- Publication
FEBS Letters, 2002, Vol 522, Issue 1-3, p71
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)02887-9