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- Title
Gastric Carcinoma in the Young: A Clinicopathological and Immunohistochemical Study.
- Authors
Radi, Michael J.; Fenoglio-Preiser, Cecilia M.; Bartow, Sue A.; Key, Charles R.; Pathak, Dorothy R.
- Abstract
Seventeen patients 40 yr of age and less with gastric carcinoma were studied retrospectively. Clinicopathological findings and survival data were collected on all patients. Immunohistochemistry for serotonin, gastrin, somatostatin, carcinoemhryonic antigen, β-human chorionic gonadotropin, and α-fetoprotein was performed and the results correlated with pathological and survival data. Patients were divided into two groups according to the presence or absence of endocrine markers in their tumors. The group with endocrine Immunoreactivity tended to present with less advanced disease and had longer survival than the group without endocrine immunoreactivity (<em>p</em> < 0.05). Although the number of patients in the study is too small to reach definite conclusions, our results are interesting in light of current knowledge of the pathobiology of gastric carcinoma and have important implications for future investigations.
- Subjects
STOMACH cancer; IMMUNOHISTOCHEMISTRY; SEROTONIN; GASTRIN; SOMATOSTATIN; CARCINOEMBRYONIC antigen; GONADOTROPIN
- Publication
American Journal of Gastroenterology (Springer Nature), 1986, Vol 81, Issue 9, p747
- ISSN
0002-9270
- Publication type
Article