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- Title
A New Mitochondrial Uncoupler Improves Metabolic Homeostasis in Mice.
- Authors
Ramshankar, Gautham; Perry, Rachel J.
- Abstract
The article discusses a study on the novel mitochondrial uncoupler SHD865 conducted by Beretta et al., published in the journal Diabetes. SHD865 shows promising effects in reducing diet-induced obesity, improving glucose tolerance, and preventing lipogenesis in mice without altering food intake or lean mass, suggesting its potential as a safe and effective antiobesity drug targeting the root cause of metabolic dysfunction.
- Subjects
HOMEOSTASIS; MITOCHONDRIA; MITOCHONDRIAL pathology; FATTY acid synthases; BODY composition; GLUCAGON-like peptide 1
- Publication
Diabetes, 2024, Vol 73, Issue 3, p357
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/dbi23-0033