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- Title
Achieving Long-Term Maintenance of Euglycemia in Subjects with Type 2 Diabetes with Continuous Subcutaneous Insulin Infusion: Over 10 Year Retrospective Observation.
- Authors
Soobong Choi; Lee, Jun H.; Do Y Kim; Jihang Choi; Hyunju An; Sunmi Lee; Yun H. Noh
- Abstract
Large prospective studies have demonstrated that good glycemic control in diabetes is associated with reduced development of diabetic complications. However, it is not common to achieve and maintain euglycemia in clinical practice because of the progressive nature of diabetes and misunderstanding of the pathophysiology of the disease. We hypothesized that intensive insulin treatment has long-term beneficial effects in type 2 diabetic patients by compensating the progressive impairment of β-cell function. Continuous subcutaneous insulin infusion (CSII) using insulin pump was used to provide the physiologic insulin requirements delicately. The retrospective clinical records of type 2 diabetic patients with long duration of CSII (n=17, male 47%, age 55.9±8.0, BMI 24.1±3.1, CSII duration 10.2±2.5 years) who admitted to Diabetes Center at Konkuk University Hospital since 1993 were analyzed. At baseline, all the subjects except one had long-standing type 2 diabetes (disease duration 8.5±6.0 years) and had uncontrolled hyperglycemia (HbA[sub 1]c 10.0±2.7%) in spite of full dose of oral hypoglycemic agents and/or intermediate acting insulin. At present, HbA[sub 1]c level has improved (6.5±1.1% vs baseline 10.0±2.7%, p <0.001), diastolic BP has decreased (77.8±6.7 vs baseline 87.6±8.3 mmHg, p <0.05), serum HDL and LDL levels has improved without lipid lowering medication (52.8±9.7 and 129.5±35.6 mg/dL vs baseline 33.5±9.5 and 146±46.7, respectively, p<0.05), and serum creatinine did not increase over 10 years (below <1.3mg/dL, except one). While, no significant change of BMI was observed (p=0.61 vs baseline). In conclusion, ten years of CSII treatment in type 2 diabetic patients had long-term benefits in maintenance of euglycemia and improvement of major cardiovascular risk factors.
- Subjects
DIABETES complications; TYPE 2 diabetes; PEOPLE with diabetes; INSULIN pumps; DRUG infusion pumps
- Publication
Diabetes, 2007, Vol 56, pA533
- ISSN
0012-1797
- Publication type
Article