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- Title
Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain.
- Authors
Antunes, Flavia Tasmin Techera; Campos, Maria Martha; Carvalho, Vanice de Paula Ricardo; da Silva Junior, Claudio Antonio; Magno, Luiz Alexandre Viana; de Souza, Alessandra Hubner; Gomez, Marcus Vinicius
- Abstract
Voltage-gated calcium channels (VGCCs) are targeted to treat pain conditions. Since the discovery of their relation to pain processing control, they are investigated to find new strategies for better pain control. This review provides an overview of naturally based and synthetic VGCC blockers, highlighting new evidence on the development of drugs focusing on the VGCC subtypes as well as mixed targets with pre-clinical and clinical analgesic effects.
- Subjects
CALCIUM channels; DRUG development; PAIN management; SYNTHETIC biology
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 11, p9223
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24119223