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- Title
The EPH/Ephrin System in Colorectal Cancer.
- Authors
Papadakos, Stavros P.; Petrogiannopoulos, Leonidas; Pergaris, Alexandros; Theocharis, Stamatios
- Abstract
The EPH/ephrin system constitutes a bidirectional signaling pathway comprised of a family of tyrosine kinase receptors in tandem with their plasma membrane-bound ligand (ephrins). Its significance in a wide variety of physiologic and pathologic processes has been recognized during the past decades. In carcinogenesis, EPH/ephrins coordinate a wide spectrum of pathologic processes, such as angiogenesis, vessel infiltration, and metastasis. Despite the recent advances in colorectal cancer (CRC) diagnosis and treatment, it remains a leading cause of death globally, accounting for 9.2% of all cancer deaths. A growing body of literature has been published lately revitalizing our scientific interest towards the role of EPH/ephrins in pathogenesis and the treatment of CRC. The aim of the present review is to present the recent CRC data which might lead to clinical practice changes in the future.
- Subjects
EPHRIN receptors; COLORECTAL cancer; PATHOGENESIS; EPHRINS; PROTEIN-tyrosine kinases; CAUSES of death
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 5, p2761
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23052761