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- Title
Sialic Acid—Modified Nanoparticles—New Approaches in the Glioma Management—Perspective Review.
- Authors
Wielgat, Przemyslaw; Niemirowicz-Laskowska, Katarzyna; Wilczewska, Agnieszka Z.; Car, Halina
- Abstract
The cell surface is covered by a dense and complex network of glycans attached to the membrane proteins and lipids. In gliomas, the aberrant sialylation, as the final stage of glycosylation, is an important regulatory mechanism of malignant cell behavior and correlates with worse prognosis. Better understanding of the role of sialylation in cellular and molecular processes opens a new way in the development of therapeutic tools for human brain tumors. According to the recent clinical observation, the cellular heterogeneity, activity of brain cancer stem cells (BCSCs), immune evasion, and function of the blood–brain barrier (BBB) are attractive targets for new therapeutic strategies. In this review, we summarize the importance of sialic acid-modified nanoparticles in brain tumor progression.
- Subjects
GLIOMAS; BRAIN tumors; NEURAL stem cells; CANCER stem cells; CANCER cells
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 14, p7494
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22147494