We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Re-Setting the Circadian Clock Using Exercise against Sarcopenia.
- Authors
Choi, Youngju; Cho, Jinkyung; No, Mi-Hyun; Heo, Jun-Won; Cho, Eun-Jeong; Chang, Eunwook; Park, Dong-Ho; Kang, Ju-Hee; Kwak, Hyo-Bum
- Abstract
Sarcopenia is defined as the involuntary loss of skeletal muscle mass and function with aging and is associated with several adverse health outcomes. Recently, the disruption of regular circadian rhythms, due to shift work or nocturnal lifestyle, is emerging as a novel deleterious factor for the development of sarcopenia. The underlying mechanisms responsible for circadian disruption-induced sarcopenia include molecular circadian clock and mitochondrial function associated with the regulation of circadian rhythms. Exercise is a potent modulator of skeletal muscle metabolism and is considered to be a crucial preventative and therapeutic intervention strategy for sarcopenia. Moreover, emerging evidence shows that exercise, acting as a zeitgeber (time cue) of the skeletal muscle clock, can be an efficacious tool for re-setting the clock in sarcopenia. In this review, we provide the evidence of the impact of circadian disruption on skeletal muscle loss resulting in sarcopenia. Furthermore, we highlight the importance of exercise timing (i.e., scheduled physical activity) as a novel therapeutic strategy to target circadian disruption in skeletal muscle.
- Subjects
SARCOPENIA; SKELETAL muscle; MUSCLE mass; MUSCLE metabolism; MOLECULAR clock
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 9, p3106
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21093106