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- Title
Tat-Biliverdin Reductase A Exerts a Protective Role in Oxidative Stress-Induced Hippocampal Neuronal Cell Damage by Regulating the Apoptosis and MAPK Signaling.
- Authors
Kim, Sang Jin; Shin, Min Jea; Kim, Dae Won; Yeo, Hyeon Ji; Yeo, Eun Ji; Choi, Yeon Joo; Sohn, Eun Jeong; Han, Kyu Hyung; Park, Jinseu; Lee, Keun Wook; Park, Jong Kook; Cho, Yong-Jun; Kim, Duk-Soo; Eum, Won Sik; Choi, Soo Young
- Abstract
Reactive oxygen species (ROS) is major risk factor in neuronal diseases including ischemia. Although biliverdin reductase A (BLVRA) plays a pivotal role in cell survival via its antioxidant function, its role in hippocampal neuronal (HT-22) cells and animal ischemic injury is not clearly understood yet. In this study, the effects of transducible fusion protein Tat-BLVRA on H2O2-induced HT-22 cell death and in an animal ischemia model were investigated. Transduced Tat-BLVRA markedly inhibited cell death, DNA fragmentation, and generation of ROS. Transduced Tat-BLVRA inhibited the apoptosis and mitogen activated protein kinase (MAPK) signaling pathway and it passed through the blood-brain barrier (BBB) and significantly prevented hippocampal cell death in an ischemic model. These results suggest that Tat-BLVRA provides a possibility as a therapeutic molecule for ischemia.
- Subjects
CELL death; DISEASE risk factors; APOPTOSIS; CHIMERIC proteins; ANIMAL mortality
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 8, p2672
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21082672