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- Title
Anti-Biofilm Performance of Three Natural Products against Initial Bacterial Attachment.
- Authors
Salta, Maria; Wharton, Julian A.; Dennington, Simon P.; Stoodley, Paul; Stokes, Keith R.
- Abstract
Marine bacteria contribute significantly towards the fouling consortium, both directly (modern foul release coatings fail to prevent "slime" attachment) and indirectly (biofilms often excrete chemical cues that attract macrofouling settlement). This study assessed the natural product anti-biofilm performance of an extract of the seaweed, Chondrus crispus, and two isolated compounds from terrestrial sources, (+)-usnic acid and juglone, against two marine biofilm forming bacteria, Cobetia marina and Marinobacter hydrocarbonoclasticus. Bioassays were developed using quantitative imaging and fluorescent labelling to test the natural products over a range of concentrations against initial bacterial attachment. All natural products affected bacterial attachment; however, juglone demonstrated the best anti-biofilm performance against both bacterial species at a concentration range between 5-20 ppm. In addition, for the first time, a dose-dependent inhibition (hormetic) response was observed for natural products against marine biofilm forming bacteria.
- Subjects
BACTERIAL adhesion; BIOFILMS; NATURAL products; MARINE bacteria; CONTROLLED release drugs; MARINE algae; PLANT extracts; CHONDRUS crispus
- Publication
International Journal of Molecular Sciences, 2013, Vol 14, Issue 11, p21757
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms141121757