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- Title
Ethyl 7-Methyl-1-(4-nitrophenyl)-5-phenyl-3-(thiophen-2-yl)-1,5-dihydro-[1,2,4]triazolo [4,3-a]pyrimidine-6-carboxylate.
- Authors
Gomha, Sobhi M.; Muhammad, Zeinab A.; Edrees, Mastoura M.
- Abstract
A novel compound, ethyl 7-methyl-1-(4-nitrophenyl)-5-phenyl-3-(thiophen-2-yl)-1,5-dihydro[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylate (7) was synthesized by reaction of N-(4-nitrophenyl)thiophene-2-carbohydrazonoyl chloride (1) with ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (2). The mechanism of the studied reaction is discussed and the assigned structure was confirmed by elemental analysis and spectral data. Moreover, the in vitro antitumor activities against human lung (A-549) and human hepatocellular carcinoma (HepG-2) cell lines were determined by the MTT method, and the results indicated a high potency compared with the employed standard antitumor drug (Cisplatin).
- Subjects
METHYL groups; THIOPHENES; PYRIMIDINES; CARBOXYLATES; CHEMICAL reactions; CHEMICAL synthesis
- Publication
Molbank, 2017, Vol 2017, Issue 2, pm942
- ISSN
1422-8599
- Publication type
Article
- DOI
10.3390/M942