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- Title
The long-acting beta-agonist controversy: A clinical dilemma.
- Authors
Lang, David M.; Davis, Ray S.
- Abstract
The Food and Drug Administration approved new safety labeling on March 2, 2006 for medication containing salmeterol, a long-acting β-agonist (LABA), because of data suggesting an increased risk of fatal or potentially fatal asthma episodes. The "black box" warning, public health advisory, and label change for salmeterol, salmeterol–fluticasone combination, and formoterol has heightened public and physician concern over the risk-to-benefit ratio and the medicolegal implications of prescribing these agents for patients with asthma. A problem-based learning (PBL) case was presented to several breakout groups at the Eastern Allergy Conference, May 6, 2006, in Naples, FL, focusing on the LABA controversy in the context of an actual patient. The consensus of opinion during the interactive group sessions among ∼100 allergists was that (1) the patient had poorly controlled asthma on inhaled corticosteroid (ICS) monotherapy and that warranted a change of therapy; (2) each physician must choose which option presents the best benefit-to-risk ratio after a thorough and open discussion with the patient; (3) of the several choices for step-up therapy when a patient is not well controlled on an ICS alone, the best choice based on current evidence is combined ICS plus LABA. After the PBL case discussion, a didactic lecture was presented describing the evidence pertaining to the LABA controversy, which is detailed in this article.
- Subjects
ASTHMA; RESPIRATORY allergy; LUNG diseases; THERAPEUTICS; CLINICAL medicine; ADRENERGIC beta agonists
- Publication
Allergy & Asthma Proceedings, 2007, Vol 28, Issue 2, p136
- ISSN
1088-5412
- Publication type
Article
- DOI
10.2500/aap.2007.28.2980