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- Title
The gp130/STAT3 signaling pathway mediates β-adrenergic receptor-induced atrial natriuretic factor expression in cardiomyocytes.
- Authors
Hui Zhang; Wei Feng; Wenqiang Liao; Xiaowei Ma; Qide Han; Youyi Zhang
- Abstract
β-Adrenergic receptor (β-AR)-induced cardiac remodeling is closely linked with the re-expression of the atrial natriuretic factor (ANF) gene. However, the exact molecular mechanism of this response remains elusive. Here, we demonstrate that the β-AR agonist isoproterenol potently evokes the tyrosine phosphorylation of STAT3 and increases its transcriptional activity in an extracellularly regulated kinase 1/2 and glycoprotein (gp)130 signaling-dependent manner in rat cardiomyocytes. Interestingly, both specific silencing of signal transducers and activators of transcription 3 (STAT3) expression by lentivirus-mediated RNA interference and antagonism of gp130 signaling lead to significant inhibition of isoproterenol-stimulated ANF expression. Together, these results indicate that gp130/STAT3 signaling has an essential role in ANF expression by β-AR stimulation.
- Subjects
ATRIAL natriuretic peptides; ADRENERGIC receptors; HEART cells; AMINO acids; HEART atrium
- Publication
FEBS Journal, 2008, Vol 275, Issue 14, p3590
- ISSN
1742-464X
- Publication type
Article
- DOI
10.1111/j.1742-4658.2008.06504.x