We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Crystal forms of a capsaicin derivative analgesic DA-5018.
- Authors
Lee, E.-A.; Sohn, Y. T.
- Abstract
DA-5018 is a new capsaicin derivative and has analgesic effect. The objective of this work was to investigate the existence of polymorphs and pseudopolymorphs of DA-5018 and the transformation of crystal forms. Eight crystal forms of DA-5018 have been isolated by recrystallization and characterized by powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TG). The PXRD and DSC patterns of the eight crystal forms were different respectively. In the dissolution studies in simulated intestinal fluid at 37±0.5°C, the solubility of Form 2 was the highest. And the solubility in water decreased in rank order: Form 2>Form 3>Form 1>Form 5>Form 7>Form 4>Form 6>Form 8. Eight crystal forms were shown to have a good physical stability at room temperature for 60 days.
- Subjects
CAPSAICIN; ANALGESICS; RECRYSTALLIZATION (Metallurgy); PHYSICAL &; theoretical chemistry; CALORIMETRY; THERMAL analysis
- Publication
Journal of Thermal Analysis & Calorimetry, 2008, Vol 93, Issue 3, p871
- ISSN
1388-6150
- Publication type
Article
- DOI
10.1007/s10973-008-9076-1