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- Title
Transcriptional and post-transcriptional regulation of genes encoding secretory proteins in Aspergillus oryzae.
- Authors
Tanaka, Mizuki
- Abstract
Aspergillus oryzae , also known as the yellow koji mold, produces various hydrolytic enzymes that are widely used in different industries. Its high capacity to produce secretory proteins makes this filamentous fungus a suitable host for heterologous protein production. Amylolytic gene promoter is widely used to express heterologous genes in A. oryzae. The expression of this promoter is strictly regulated by several transcription factors, whose activation involves various factors. Furthermore, the expression levels of amylolytic and heterologous genes are post-transcriptionally regulated by mRNA degradation mechanisms in response to aberrant transcriptional termination or endoplasmic reticulum stress. This review discusses the transcriptional and post-transcriptional regulatory mechanisms controlling the expression of genes encoding secretory proteins in A. oryzae.
- Subjects
KOJI; GENETIC regulation; GENETIC transcription regulation; GENE expression; TRANSCRIPTION factors; RICE blast disease
- Publication
Bioscience, Biotechnology & Biochemistry, 2024, Vol 88, Issue 4, p381
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1093/bbb/zbae004