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- Title
Synthesis and structure--activity relationship of kujigamberol B, a dinorlabdane diterpenoid isolated from an ancient Kuji amber.
- Authors
Sakura Kishibata; Kurumi Tanaka; Tatsuo Saito; Ken-ichi Kimura; Arata Yajima
- Abstract
The versatile methodology was developed for synthesizing kujigamberol B, a dinorlabdane diterpenoid isolated from the methanol extract of Kuji amber. A highly efficient intramolecular cyclization is followed by a Sonogashira-coupling reaction during the total synthesis. The synthesized compounds were evaluated for the growth-restoring activity against the mutant yeast (zds1Δ erg3Δ pdr1Δ pdr3Δ) and for the degranulation of RBL-2H3 cells. We found that in both activities, primary alcohol and secondary alcohol analogs are as active as kujigamberol B.
- Subjects
CHEMICAL synthesis; TRIPTOLIDE; RING formation (Chemistry)
- Publication
Bioscience, Biotechnology & Biochemistry, 2023, Vol 87, Issue 6, p575
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1093/bbb/zbad027