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- Title
3D radial projection technique with ultrashort echo times for sodium MRI: Clinical applications in human brain and skeletal muscle.
- Authors
Nielles-Vallespin, Sònia; Weber, Marc-André; Bock, Michael; Bongers, André; Speier, Peter; Combs, Stephanie E.; Wöhrle, Johannes; Lehmann-Horn, Frank; Essig, Marco; Schad, Lothar R.
- Abstract
23Na MRI has the potential to noninvasively detect sodium (Na) content changes in vivo. The goal of this study was to implement 23Na MRI in a clinical setting for neurooncological and muscular imaging. Due to the biexponential T2 decay of the tissue Na signal with a short component, which ranges between 0.5-8 ms, the measurement of total Na content requires imaging techniques with echo times (TEs) below 0.5 ms. A 3D radial pulse sequence with a TE of 0.2 ms at a spatial resolution of 4 × 4 × 4 mm3 was developed that allows the acquisition and presentation of Na images on the scanner. This sequence was evaluated in patients with low- and high-grade gliomas, and higher 23Na MR signals corresponding to an increased Na content were found in the tumor regions. The contrast-to-noise ratio (CNR) between tumor and white matter increased from 0.8 ± 0.2 to 1.3 ± 0.3 with tumor grade. In patients with an identified muscular 23Na channelopathy (Paramyotonia congenita (PC)), induced muscle weakness led to a signal increase of ∼18% in the 23Na MR images, which was attributed to intracellular Na+ accumulation in this region. Magn Reson Med 57:74-81, 2007. © 2006 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2007, Vol 57, Issue 1, p74
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.21104