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- Title
Resistance to neoadjuvant chemotherapy in breast cancer with proven intratumoral heterogeneity: a clinical case.
- Authors
Nanev, Vasil D.; Naneva, Silvia V.; Yordanov, Angel D.; Strashilov, Strahil A.; Ivanov, Ivan N.
- Abstract
Breast cancer (BC) is the most common cancer in women in Bulgaria, with a frequency of 26.7% of all newly registered cancer cases in 2020 and ranks first in mortality. In recent years, research and studies have confirmed that breast cancer is a highly heterogeneous disease at the morphological, genomic, and transcriptomic levels, manifested clinically with different behavior and response to therapy. The gold standard for breast cancer diagnostic management is based upon three diagnostic methods, including clinical examination, imaging, and percutaneous biopsy. The main percutaneous biopsy method is an ultrasound-guided core-needle biopsy. It is sufficiently representative of the composition of the tumor although it represents a limited part of it, and some cellular subpopulations are often scantly represented or completely absent. We present a case of a 41yearold breast cancer patient with primary intratumoral morphological heterogeneity diagnosed through coreneedle biopsy and with primary resistance to neoadjuvant targeted therapy.
- Subjects
NEOADJUVANT chemotherapy; TRANSCRIPTOMES; BREAST cancer; NEEDLE biopsy; CLINICAL trials
- Publication
Oncology in Clinical Practice (2450-1654), 2022, Vol 18, Issue 2, p134
- ISSN
2450-1654
- Publication type
Article
- DOI
10.5603/OCP.2022.0015