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Title
Regioselective Synthesis of 2-oxo-2,8-dihydro-[l,2,4] oxadiazolo [2,3- a]pyrimidine-7-carbamates: A New Class of Antihypertensive Peripheral Vasodilators.
The synthesis of new 2-oxo-2,8-dihydro-[l,2,4]-oxadiazoo-[2,3- a] pyrimidine-carbamates 3 described in this paper is based upon a regioselective heterocyclization of the pyrimidine-2,6-bis (alkoxycarbonylamino) N-oxides 4. Structural and mechanistic aspects of that cyclizalion are discussed.