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- Title
Solution and solid‐state <sup>33</sup>S NMR studies of <sup>33</sup>S‐labeled taurine.
- Authors
Masuda, Yuichi; Ohki, Shinobu; Mogami, Yuuki; Deguchi, Kenzo; Hashi, Kenjiro; Goto, Atsushi; Shimizu, Tadashi; Yamada, Kazuhiko
- Abstract
Sulfur‐33(33S) stable‐isotope labeled taurine, 2‐aminoethanesulfonic acid, has been synthesized, and a series of solution and solid‐state 33S nuclear magnetic resonance (NMR) experiments at 14.1 and 18.8 T, respectively, have been carried out at room temperature. The single peak of a solution 33S NMR spectrum in 0.1‐mM [33S]‐taurine in D2O can be observed with the signal‐to‐noise (S/N) ratio of 9 in 40,000 scans, which paves the way toward in vivo analysis of pharmacokinetics and metabolism of 33S‐labeled taurine. Undistorted magic‐angle‐spinning (MAS) and static 33S NMR spectra of polycrystalline [33S]‐taurine are observed with sufficient S/N ratios for analysis, and the magnitudes of 33S EFG and CS tensors can be obtained.
- Subjects
TAURINE; NUCLEAR magnetic resonance; NUCLEAR magnetic resonance spectroscopy; MAGIC angle spinning; DEUTERIUM oxide
- Publication
Magnetic Resonance in Chemistry, 2023, Vol 61, Issue 11, p589
- ISSN
0749-1581
- Publication type
Article
- DOI
10.1002/mrc.5387