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- Title
Electrocorticography and seizure outcomes in children with lesional epilepsy.
- Authors
Gelinas, Jennifer N.; Battison, Andrew W.; Smith, Sherry; Connolly, Mary B.; Steinbok, Paul
- Abstract
Purpose: The use of electrocorticographically (ECoG)-guided cortical resection in children with lesional epilepsy is controversial. Given the important developmental issues associated with recurrent childhood seizures, sustained seizure control is a key therapeutic goal. We therefore evaluated the effect of the decision to perform lesionectomy or ECoG-guided cortical resection on seizure outcome and surgical morbidity in the pediatric population. Methods: We retrospectively analyzed seizure outcomes in 67 patients between the ages of 3 months and 16 years who underwent surgery for lesional epilepsy at British Columbia Children's Hospital. Thirty-four patients underwent ECoG, and 33 patients had lesionectomy without ECoG. Results: One year post-operatively, 80% of patients who had ECoG-guided cortical resection or lesionectomy were seizure free. However, there was a trend toward improved seizure freedom in patients who had ECoG at most recent follow-up (79% patients with ECoG seizure free, vs. 61% with lesionectomy only; mean follow-up time 5.8 year, P = 0.078). There was no increase in neurological morbidity in patients who had ECoG-guided cortical resection, and these patients were less likely to experience repeat epilepsy surgery. Conclusions: Overall, using ECoG to guide additional cortical resection may lead to more robust seizure freedom in children with lesional epilepsy without increasing their risk of surgical morbidity.
- Subjects
BRITISH Columbia; BRAIN tumors; ELECTROENCEPHALOGRAPHY; SPASMS; PEDIATRICS; CHILDREN'S hospitals; CHILDREN; EPILEPSY surgery; BRAIN diseases
- Publication
Child's Nervous System, 2011, Vol 27, Issue 3, p381
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-010-1279-7