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- Title
Mutation ∆K281 in MAPT causes Pick's disease.
- Authors
Schweighauser, Manuel; Garringer, Holly J.; Klingstedt, Therése; Nilsson, K. Peter R.; Masuda-Suzukake, Masami; Murrell, Jill R.; Risacher, Shannon L.; Vidal, Ruben; Scheres, Sjors H. W.; Goedert, Michel; Ghetti, Bernardino; Newell, Kathy L.
- Abstract
Two siblings with deletion mutation ∆K281 in MAPT developed frontotemporal dementia. At autopsy, numerous inclusions of hyperphosphorylated 3R Tau were present in neurons and glial cells of neocortex and some subcortical regions, including hippocampus, caudate/putamen and globus pallidus. The inclusions were argyrophilic with Bodian silver, but not with Gallyas–Braak silver. They were not labelled by an antibody specific for tau phosphorylated at S262 and/or S356. The inclusions were stained by luminescent conjugated oligothiophene HS-84, but not by bTVBT4. Electron cryo-microscopy revealed that the core of tau filaments was made of residues K254-F378 of 3R Tau and was indistinguishable from that of Pick's disease. We conclude that MAPT mutation ∆K281 causes Pick's disease.
- Subjects
DELETION mutation; GLOBUS pallidus; FRONTOTEMPORAL dementia; NEUROGLIA; TAU proteins
- Publication
Acta Neuropathologica, 2023, Vol 146, Issue 2, p211
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-023-02598-6