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- Title
The role of miRNAs in viral myocarditis, and its possible implication in induction of mRNA-based COVID-19 vaccines-induced myocarditis.
- Authors
AbdelMassih, Antoine; Agha, Hala; El-Saiedi, Sonia; El-Sisi, Amal; El Shershaby, Meryam; Gaber, Hanya; Ismail, Habiba-Allah; El-Husseiny, Nadine; Amin, Abeer Reda; ElBoraie, Aly; Ayad, Aya; Menshawey, Esraa; Sefein, Fady; Osman, Ibrahim Ihab; Moursi, Mai; Hanafy, Maram; Abdelaziz, Mariam Sherif; Arsanyous, Mariem Badr; Khaled-Ibn-El-Walid, Mariam; Tawfik, Marwa Gamal
- Abstract
Background: Several reports of unheeded complications secondary to the current mass international rollout of SARS-COV-2 vaccines, one of which is myocarditis occurring with the FDA fully approved vaccine, Pfizer, and others. Certain miRNAs (non-coding RNA sequences) are involved in the pathogenesis in viral myocarditis, and those miRNAs are interestingly upregulated in severe COVID-19. We hypothesize that the use of mRNA-based vaccines may be triggering the release of host miRNAs or that trigger the occurrence of myocarditis. This is based on the finding of altered host miRNA expression promoting virus-induced myocarditis. Short conclusion: In conclusion, miRNAs are likely implicated in myocarditis associated with mRNA vaccines. Our hypothesis suggests the use of miRNA as a biomarker for the diagnosis of mRNA vaccine-induced myocarditis. Additionally, the interplay between viral miRNA and the host immune system could alter inflammatory profiles, hence suggesting the use of therapeutic inhibition to prevent such complications.
- Subjects
UNITED States. Food &; Drug Administration; MESSENGER RNA; MYOCARDITIS; GENE expression; MICRORNA; NON-coding RNA
- Publication
Bulletin of the National Research Centre, 2022, Vol 46, Issue 1, p1
- ISSN
2522-8307
- Publication type
Article
- DOI
10.1186/s42269-022-00955-1