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- Title
Prognostic Value of Tiam1 and Rac1 Overexpression in Nasopharyngeal Carcinoma.
- Authors
Yan Qi; Bo Huang; Linlin Yu; Qi Wang; Guiping Lan; Qiuhang Zhang
- Abstract
AbstractPurpose:This study is designed to investigate the roles of Tiam1 and Rac1 in nasopharyngeal carcinoma (NPC). Methods:NPC samples (n = 102) were analyzed with immunohistochemistry for Tiam1 and Rac1 proteins, 28 of which were also analyzed with quantitative RT-PCR and Western blots for Tiam1 and Rac1 mRNA and protein expression. The expression of Tiam1 and Rac1 in noncancerous nasopharyngeal tissue (n = 26) acted as a control. The expression was gauged regarding stage, grade and survival. Results:Tiam1 and Rac1 were overexpressed in NPC cells and their protein upregulation was significantly associated with stage and grading (p < 0.05 for all). Cox regression analysis revealed Tiam1 and Rac1 protein upregulation was correlated with lower disease-free and overall survival rates (p < 0.001). Conclusions:Upregulation of Tiam1 and Rac1 proteins may play a critical role in tumor progression of NPC, and work as a prognostic factor for NPC patients.Copyright © 2009 S. Karger AG, Basel
- Subjects
NASOPHARYNX cancer; LYMPHOMAS; T cells; GENE expression; IMMUNOHISTOCHEMISTRY; REVERSE transcriptase polymerase chain reaction; REGRESSION analysis; CANCER invasiveness; PROGNOSIS
- Publication
ORL, 2009, Vol 71, Issue 3, p163
- ISSN
0301-1569
- Publication type
Article
- DOI
10.1159/000223440